Extending gene ontology in the context of extracellular RNA and vesicle communication
Identifieur interne : 001F19 ( Main/Exploration ); précédent : 001F18; suivant : 001F20Extending gene ontology in the context of extracellular RNA and vesicle communication
Auteurs : Kei-Hoi Cheung [États-Unis] ; Shivakumar Keerthikumar ; Paola Roncaglia ; Sai Lakshmi Subramanian [États-Unis] ; Matthew E. Roth [États-Unis] ; Monisha Samuel ; Sushma Anand ; Lahiru Gangoda ; Stephen Gould [États-Unis] ; Roger Alexander [États-Unis] ; David Galas [États-Unis] ; Mark B. Gerstein [États-Unis] ; Andrew F. Hill ; Robert R. Kitchen [États-Unis] ; Jan Lötvall [Suède] ; Tushar Patel [États-Unis] ; Dena C. Procaccini [États-Unis] ; Peter Quesenberry [États-Unis] ; Joel Rozowsky [États-Unis] ; Robert L. Raffai [États-Unis] ; Aleksandra Shypitsyna ; Andrew I. Su [États-Unis] ; Clotilde Théry [France] ; Kasey Vickers [États-Unis] ; Marca H. M. Wauben [Pays-Bas] ; Suresh Mathivanan ; Aleksandar Milosavljevic [États-Unis] ; Louise C. Laurent [États-Unis]Source :
- Journal of Biomedical Semantics [ 2041-1480 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : RNA.
- genetics : Extracellular Vesicles.
- Databases, Genetic, Gene Ontology, Humans, Molecular Sequence Annotation, Web Browser.
Abstract
To address the lack of standard terminology to describe extracellular RNA (exRNA) data/metadata, we have launched an inter-community effort to extend the Gene Ontology (GO) with subcellular structure concepts relevant to the exRNA domain. By extending GO in this manner, the exRNA data/metadata will be more easily annotated and queried because it will be based on a shared set of terms and relationships relevant to extracellular research.
By following a consensus-building process, we have worked with several academic societies/consortia, including ERCC, ISEV, and ASEMV, to identify and approve a set of exRNA and extracellular vesicle-related terms and relationships that have been incorporated into GO. In addition, we have initiated an ongoing process of extractions of gene product annotations associated with these terms from Vesiclepedia and ExoCarta, conversion of the extracted annotations to Gene Association File (GAF) format for batch submission to GO, and curation of the submitted annotations by the GO Consortium. As a use case, we have incorporated some of the GO terms into annotations of samples from the exRNA Atlas and implemented a faceted search interface based on such annotations.
We have added 7 new terms and modified 9 existing terms (along with their synonyms and relationships) to GO. Additionally, 18,695 unique coding gene products (mRNAs and proteins) and 963 unique non-coding gene products (ncRNAs) which are associated with the terms: “extracellular vesicle”, “extracellular exosome”, “apoptotic body”, and “microvesicle” were extracted from ExoCarta and Vesiclepedia. These annotations are currently being processed for submission to GO.
As an inter-community effort, we have made a substantial update to GO in the exRNA context. We have also demonstrated the utility of some of the new GO terms for sample annotation and metadata search.
Url:
DOI: 10.1186/s13326-016-0061-5
PubMed: 27076901
PubMed Central: 4830068
Affiliations:
- France, Pays-Bas, Suède, États-Unis
- Californie, Connecticut, Floride, Maryland, Rhode Island, Tennessee, Texas, Utrecht (province), Washington (État), Île-de-France
- Paris, Utrecht
- Université d'Utrecht
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000D44
- to stream Pmc, to step Curation: 000C05
- to stream Pmc, to step Checkpoint: 000946
- to stream PubMed, to step Corpus: 002032
- to stream PubMed, to step Curation: 002007
- to stream PubMed, to step Checkpoint: 002007
- to stream Ncbi, to step Merge: 003411
- to stream Ncbi, to step Curation: 003411
- to stream Ncbi, to step Checkpoint: 003411
- to stream Main, to step Merge: 001F18
- to stream Main, to step Curation: 001F19
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Extending gene ontology in the context of extracellular RNA and vesicle communication</title><author><name sortKey="Cheung, Kei Hoi" sort="Cheung, Kei Hoi" uniqKey="Cheung K" first="Kei-Hoi" last="Cheung">Kei-Hoi Cheung</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Emergency Medicine, Yale Center for Medical Informatics, Yale University School of Medicine, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Emergency Medicine, Yale Center for Medical Informatics, Yale University School of Medicine, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff2">VA Connecticut Healthcare System, West Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>VA Connecticut Healthcare System, West Haven</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Keerthikumar, Shivakumar" sort="Keerthikumar, Shivakumar" uniqKey="Keerthikumar S" first="Shivakumar" last="Keerthikumar">Shivakumar Keerthikumar</name><affiliation><nlm:aff id="Aff3">Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3086 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Roncaglia, Paola" sort="Roncaglia, Paola" uniqKey="Roncaglia P" first="Paola" last="Roncaglia">Paola Roncaglia</name><affiliation><nlm:aff id="Aff4">European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD UK</nlm:aff><wicri:noCountry code="subfield">CB10 1SD UK</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff22">Gene Ontology Consortium (GOC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Subramanian, Sai Lakshmi" sort="Subramanian, Sai Lakshmi" uniqKey="Subramanian S" first="Sai Lakshmi" last="Subramanian">Sai Lakshmi Subramanian</name><affiliation wicri:level="2"><nlm:aff id="Aff5">Bioinformatics Research Laboratory, Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Bioinformatics Research Laboratory, Department of Molecular & Human Genetics, Baylor College of Medicine, Houston</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Roth, Matthew E" sort="Roth, Matthew E" uniqKey="Roth M" first="Matthew E." last="Roth">Matthew E. Roth</name><affiliation wicri:level="2"><nlm:aff id="Aff5">Bioinformatics Research Laboratory, Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Bioinformatics Research Laboratory, Department of Molecular & Human Genetics, Baylor College of Medicine, Houston</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Samuel, Monisha" sort="Samuel, Monisha" uniqKey="Samuel M" first="Monisha" last="Samuel">Monisha Samuel</name><affiliation><nlm:aff id="Aff3">Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3086 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Anand, Sushma" sort="Anand, Sushma" uniqKey="Anand S" first="Sushma" last="Anand">Sushma Anand</name><affiliation><nlm:aff id="Aff3">Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3086 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Gangoda, Lahiru" sort="Gangoda, Lahiru" uniqKey="Gangoda L" first="Lahiru" last="Gangoda">Lahiru Gangoda</name><affiliation><nlm:aff id="Aff3">Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3086 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Gould, Stephen" sort="Gould, Stephen" uniqKey="Gould S" first="Stephen" last="Gould">Stephen Gould</name><affiliation wicri:level="2"><nlm:aff id="Aff6">Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff23">American Society for Exosomes and Microvesicles (ASEMV), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Alexander, Roger" sort="Alexander, Roger" uniqKey="Alexander R" first="Roger" last="Alexander">Roger Alexander</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Pacific Northwest Diabetes Research Institute, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Pacific Northwest Diabetes Research Institute, Seattle</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Galas, David" sort="Galas, David" uniqKey="Galas D" first="David" last="Galas">David Galas</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Pacific Northwest Diabetes Research Institute, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Pacific Northwest Diabetes Research Institute, Seattle</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Gerstein, Mark B" sort="Gerstein, Mark B" uniqKey="Gerstein M" first="Mark B." last="Gerstein">Mark B. Gerstein</name><affiliation wicri:level="2"><nlm:aff id="Aff8">Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Molecular Biophysics and Biochemistry, Yale University, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff9">Department of Computer Science, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Computer Science, Yale University, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff10">Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Program in Computational Biology and Bioinformatics, Yale University, New Haven</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Hill, Andrew F" sort="Hill, Andrew F" uniqKey="Hill A" first="Andrew F." last="Hill">Andrew F. Hill</name><affiliation><nlm:aff id="Aff3">Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3086 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff24">International Society for Extracellular Vesicles (ISEV), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Kitchen, Robert R" sort="Kitchen, Robert R" uniqKey="Kitchen R" first="Robert R." last="Kitchen">Robert R. Kitchen</name><affiliation wicri:level="2"><nlm:aff id="Aff8">Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Molecular Biophysics and Biochemistry, Yale University, New Haven</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Lotvall, Jan" sort="Lotvall, Jan" uniqKey="Lotvall J" first="Jan" last="Lötvall">Jan Lötvall</name><affiliation wicri:level="1"><nlm:aff id="Aff11">University of Gothenburg, Gothenburg, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation><affiliation><nlm:aff id="Aff24">International Society for Extracellular Vesicles (ISEV), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Patel, Tushar" sort="Patel, Tushar" uniqKey="Patel T" first="Tushar" last="Patel">Tushar Patel</name><affiliation wicri:level="2"><nlm:aff id="Aff12">Mayo Clinic, Jacksonville, FL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Procaccini, Dena C" sort="Procaccini, Dena C" uniqKey="Procaccini D" first="Dena C." last="Procaccini">Dena C. Procaccini</name><affiliation wicri:level="2"><nlm:aff id="Aff13">Division of Neuroscience and Behavior, National Institute on Drug Abuse (NIDA), Rockville, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Neuroscience and Behavior, National Institute on Drug Abuse (NIDA), Rockville</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Quesenberry, Peter" sort="Quesenberry, Peter" uniqKey="Quesenberry P" first="Peter" last="Quesenberry">Peter Quesenberry</name><affiliation wicri:level="2"><nlm:aff id="Aff14">University Medicine Comprehensive Cancer Center, Providence, RI USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Rhode Island</region></placeName><wicri:cityArea>University Medicine Comprehensive Cancer Center, Providence</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff24">International Society for Extracellular Vesicles (ISEV), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Rozowsky, Joel" sort="Rozowsky, Joel" uniqKey="Rozowsky J" first="Joel" last="Rozowsky">Joel Rozowsky</name><affiliation wicri:level="2"><nlm:aff id="Aff8">Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Molecular Biophysics and Biochemistry, Yale University, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff10">Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Program in Computational Biology and Bioinformatics, Yale University, New Haven</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Raffai, Robert L" sort="Raffai, Robert L" uniqKey="Raffai R" first="Robert L." last="Raffai">Robert L. Raffai</name><affiliation wicri:level="2"><nlm:aff id="Aff15">Department of Surgery, University of California San Francisco and VA Medical Center, San Francisco, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, University of California San Francisco and VA Medical Center, San Francisco</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Shypitsyna, Aleksandra" sort="Shypitsyna, Aleksandra" uniqKey="Shypitsyna A" first="Aleksandra" last="Shypitsyna">Aleksandra Shypitsyna</name><affiliation><nlm:aff id="Aff4">European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD UK</nlm:aff><wicri:noCountry code="subfield">CB10 1SD UK</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff22">Gene Ontology Consortium (GOC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Su, Andrew I" sort="Su, Andrew I" uniqKey="Su A" first="Andrew I." last="Su">Andrew I. Su</name><affiliation wicri:level="2"><nlm:aff id="Aff16">Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Thery, Clotilde" sort="Thery, Clotilde" uniqKey="Thery C" first="Clotilde" last="Théry">Clotilde Théry</name><affiliation wicri:level="3"><nlm:aff id="Aff17">Institut Curie, PSL Research University, INSERM U932, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, PSL Research University, INSERM U932, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation><nlm:aff id="Aff24">International Society for Extracellular Vesicles (ISEV), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Vickers, Kasey" sort="Vickers, Kasey" uniqKey="Vickers K" first="Kasey" last="Vickers">Kasey Vickers</name><affiliation wicri:level="2"><nlm:aff id="Aff18">Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Medicine, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Wauben, Marca H M" sort="Wauben, Marca H M" uniqKey="Wauben M" first="Marca H. M." last="Wauben">Marca H. M. Wauben</name><affiliation wicri:level="4"><nlm:aff id="Aff19">Department of Biochemistry & Cell Biology, Utrecht University, Utrecht, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biochemistry & Cell Biology, Utrecht University, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region><settlement type="city">Utrecht</settlement></placeName><orgName type="university">Université d'Utrecht</orgName></affiliation><affiliation><nlm:aff id="Aff24">International Society for Extracellular Vesicles (ISEV), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Mathivanan, Suresh" sort="Mathivanan, Suresh" uniqKey="Mathivanan S" first="Suresh" last="Mathivanan">Suresh Mathivanan</name><affiliation><nlm:aff id="Aff3">Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3086 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff24">International Society for Extracellular Vesicles (ISEV), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Milosavljevic, Aleksandar" sort="Milosavljevic, Aleksandar" uniqKey="Milosavljevic A" first="Aleksandar" last="Milosavljevic">Aleksandar Milosavljevic</name><affiliation wicri:level="2"><nlm:aff id="Aff5">Bioinformatics Research Laboratory, Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Bioinformatics Research Laboratory, Department of Molecular & Human Genetics, Baylor College of Medicine, Houston</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Laurent, Louise C" sort="Laurent, Louise C" uniqKey="Laurent L" first="Louise C." last="Laurent">Louise C. Laurent</name><affiliation wicri:level="2"><nlm:aff id="Aff20">Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Reproductive Medicine, University of California, San Diego, La Jolla</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27076901</idno><idno type="pmc">4830068</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830068</idno><idno type="RBID">PMC:4830068</idno><idno type="doi">10.1186/s13326-016-0061-5</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000D44</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D44</idno><idno type="wicri:Area/Pmc/Curation">000C05</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C05</idno><idno type="wicri:Area/Pmc/Checkpoint">000946</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000946</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002032</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002032</idno><idno type="wicri:Area/PubMed/Curation">002007</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002007</idno><idno type="wicri:Area/PubMed/Checkpoint">002007</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002007</idno><idno type="wicri:Area/Ncbi/Merge">003411</idno><idno type="wicri:Area/Ncbi/Curation">003411</idno><idno type="wicri:Area/Ncbi/Checkpoint">003411</idno><idno type="wicri:Area/Main/Merge">001F18</idno><idno type="wicri:Area/Main/Curation">001F19</idno><idno type="wicri:Area/Main/Exploration">001F19</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Extending gene ontology in the context of extracellular RNA and vesicle communication</title><author><name sortKey="Cheung, Kei Hoi" sort="Cheung, Kei Hoi" uniqKey="Cheung K" first="Kei-Hoi" last="Cheung">Kei-Hoi Cheung</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Emergency Medicine, Yale Center for Medical Informatics, Yale University School of Medicine, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Emergency Medicine, Yale Center for Medical Informatics, Yale University School of Medicine, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff2">VA Connecticut Healthcare System, West Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>VA Connecticut Healthcare System, West Haven</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Keerthikumar, Shivakumar" sort="Keerthikumar, Shivakumar" uniqKey="Keerthikumar S" first="Shivakumar" last="Keerthikumar">Shivakumar Keerthikumar</name><affiliation><nlm:aff id="Aff3">Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3086 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Roncaglia, Paola" sort="Roncaglia, Paola" uniqKey="Roncaglia P" first="Paola" last="Roncaglia">Paola Roncaglia</name><affiliation><nlm:aff id="Aff4">European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD UK</nlm:aff><wicri:noCountry code="subfield">CB10 1SD UK</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff22">Gene Ontology Consortium (GOC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Subramanian, Sai Lakshmi" sort="Subramanian, Sai Lakshmi" uniqKey="Subramanian S" first="Sai Lakshmi" last="Subramanian">Sai Lakshmi Subramanian</name><affiliation wicri:level="2"><nlm:aff id="Aff5">Bioinformatics Research Laboratory, Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Bioinformatics Research Laboratory, Department of Molecular & Human Genetics, Baylor College of Medicine, Houston</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Roth, Matthew E" sort="Roth, Matthew E" uniqKey="Roth M" first="Matthew E." last="Roth">Matthew E. Roth</name><affiliation wicri:level="2"><nlm:aff id="Aff5">Bioinformatics Research Laboratory, Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Bioinformatics Research Laboratory, Department of Molecular & Human Genetics, Baylor College of Medicine, Houston</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Samuel, Monisha" sort="Samuel, Monisha" uniqKey="Samuel M" first="Monisha" last="Samuel">Monisha Samuel</name><affiliation><nlm:aff id="Aff3">Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3086 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Anand, Sushma" sort="Anand, Sushma" uniqKey="Anand S" first="Sushma" last="Anand">Sushma Anand</name><affiliation><nlm:aff id="Aff3">Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3086 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Gangoda, Lahiru" sort="Gangoda, Lahiru" uniqKey="Gangoda L" first="Lahiru" last="Gangoda">Lahiru Gangoda</name><affiliation><nlm:aff id="Aff3">Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3086 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Gould, Stephen" sort="Gould, Stephen" uniqKey="Gould S" first="Stephen" last="Gould">Stephen Gould</name><affiliation wicri:level="2"><nlm:aff id="Aff6">Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff23">American Society for Exosomes and Microvesicles (ASEMV), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Alexander, Roger" sort="Alexander, Roger" uniqKey="Alexander R" first="Roger" last="Alexander">Roger Alexander</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Pacific Northwest Diabetes Research Institute, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Pacific Northwest Diabetes Research Institute, Seattle</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Galas, David" sort="Galas, David" uniqKey="Galas D" first="David" last="Galas">David Galas</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Pacific Northwest Diabetes Research Institute, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Pacific Northwest Diabetes Research Institute, Seattle</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Gerstein, Mark B" sort="Gerstein, Mark B" uniqKey="Gerstein M" first="Mark B." last="Gerstein">Mark B. Gerstein</name><affiliation wicri:level="2"><nlm:aff id="Aff8">Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Molecular Biophysics and Biochemistry, Yale University, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff9">Department of Computer Science, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Computer Science, Yale University, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff10">Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Program in Computational Biology and Bioinformatics, Yale University, New Haven</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Hill, Andrew F" sort="Hill, Andrew F" uniqKey="Hill A" first="Andrew F." last="Hill">Andrew F. Hill</name><affiliation><nlm:aff id="Aff3">Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3086 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff24">International Society for Extracellular Vesicles (ISEV), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Kitchen, Robert R" sort="Kitchen, Robert R" uniqKey="Kitchen R" first="Robert R." last="Kitchen">Robert R. Kitchen</name><affiliation wicri:level="2"><nlm:aff id="Aff8">Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Molecular Biophysics and Biochemistry, Yale University, New Haven</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Lotvall, Jan" sort="Lotvall, Jan" uniqKey="Lotvall J" first="Jan" last="Lötvall">Jan Lötvall</name><affiliation wicri:level="1"><nlm:aff id="Aff11">University of Gothenburg, Gothenburg, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation><affiliation><nlm:aff id="Aff24">International Society for Extracellular Vesicles (ISEV), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Patel, Tushar" sort="Patel, Tushar" uniqKey="Patel T" first="Tushar" last="Patel">Tushar Patel</name><affiliation wicri:level="2"><nlm:aff id="Aff12">Mayo Clinic, Jacksonville, FL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Procaccini, Dena C" sort="Procaccini, Dena C" uniqKey="Procaccini D" first="Dena C." last="Procaccini">Dena C. Procaccini</name><affiliation wicri:level="2"><nlm:aff id="Aff13">Division of Neuroscience and Behavior, National Institute on Drug Abuse (NIDA), Rockville, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Neuroscience and Behavior, National Institute on Drug Abuse (NIDA), Rockville</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Quesenberry, Peter" sort="Quesenberry, Peter" uniqKey="Quesenberry P" first="Peter" last="Quesenberry">Peter Quesenberry</name><affiliation wicri:level="2"><nlm:aff id="Aff14">University Medicine Comprehensive Cancer Center, Providence, RI USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Rhode Island</region></placeName><wicri:cityArea>University Medicine Comprehensive Cancer Center, Providence</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff24">International Society for Extracellular Vesicles (ISEV), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Rozowsky, Joel" sort="Rozowsky, Joel" uniqKey="Rozowsky J" first="Joel" last="Rozowsky">Joel Rozowsky</name><affiliation wicri:level="2"><nlm:aff id="Aff8">Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Molecular Biophysics and Biochemistry, Yale University, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff10">Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Program in Computational Biology and Bioinformatics, Yale University, New Haven</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Raffai, Robert L" sort="Raffai, Robert L" uniqKey="Raffai R" first="Robert L." last="Raffai">Robert L. Raffai</name><affiliation wicri:level="2"><nlm:aff id="Aff15">Department of Surgery, University of California San Francisco and VA Medical Center, San Francisco, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, University of California San Francisco and VA Medical Center, San Francisco</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Shypitsyna, Aleksandra" sort="Shypitsyna, Aleksandra" uniqKey="Shypitsyna A" first="Aleksandra" last="Shypitsyna">Aleksandra Shypitsyna</name><affiliation><nlm:aff id="Aff4">European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD UK</nlm:aff><wicri:noCountry code="subfield">CB10 1SD UK</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff22">Gene Ontology Consortium (GOC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Su, Andrew I" sort="Su, Andrew I" uniqKey="Su A" first="Andrew I." last="Su">Andrew I. Su</name><affiliation wicri:level="2"><nlm:aff id="Aff16">Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Thery, Clotilde" sort="Thery, Clotilde" uniqKey="Thery C" first="Clotilde" last="Théry">Clotilde Théry</name><affiliation wicri:level="3"><nlm:aff id="Aff17">Institut Curie, PSL Research University, INSERM U932, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, PSL Research University, INSERM U932, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation><nlm:aff id="Aff24">International Society for Extracellular Vesicles (ISEV), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Vickers, Kasey" sort="Vickers, Kasey" uniqKey="Vickers K" first="Kasey" last="Vickers">Kasey Vickers</name><affiliation wicri:level="2"><nlm:aff id="Aff18">Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Medicine, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Wauben, Marca H M" sort="Wauben, Marca H M" uniqKey="Wauben M" first="Marca H. M." last="Wauben">Marca H. M. Wauben</name><affiliation wicri:level="4"><nlm:aff id="Aff19">Department of Biochemistry & Cell Biology, Utrecht University, Utrecht, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biochemistry & Cell Biology, Utrecht University, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region><settlement type="city">Utrecht</settlement></placeName><orgName type="university">Université d'Utrecht</orgName></affiliation><affiliation><nlm:aff id="Aff24">International Society for Extracellular Vesicles (ISEV), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Mathivanan, Suresh" sort="Mathivanan, Suresh" uniqKey="Mathivanan S" first="Suresh" last="Mathivanan">Suresh Mathivanan</name><affiliation><nlm:aff id="Aff3">Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3086 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff24">International Society for Extracellular Vesicles (ISEV), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Milosavljevic, Aleksandar" sort="Milosavljevic, Aleksandar" uniqKey="Milosavljevic A" first="Aleksandar" last="Milosavljevic">Aleksandar Milosavljevic</name><affiliation wicri:level="2"><nlm:aff id="Aff5">Bioinformatics Research Laboratory, Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Bioinformatics Research Laboratory, Department of Molecular & Human Genetics, Baylor College of Medicine, Houston</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author><author><name sortKey="Laurent, Louise C" sort="Laurent, Louise C" uniqKey="Laurent L" first="Louise C." last="Laurent">Louise C. Laurent</name><affiliation wicri:level="2"><nlm:aff id="Aff20">Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Reproductive Medicine, University of California, San Diego, La Jolla</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff21">Extracellular RNA Communication Consortium (ERCC), ᅟ, ᅟ</nlm:aff><wicri:noCountry code="subfield">ᅟ</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of Biomedical Semantics</title><idno type="eISSN">2041-1480</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Databases, Genetic</term><term>Extracellular Vesicles (genetics)</term><term>Gene Ontology</term><term>Humans</term><term>Molecular Sequence Annotation</term><term>RNA (genetics)</term><term>Web Browser</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN (génétique)</term><term>Annotation de séquence moléculaire</term><term>Bases de données génétiques</term><term>Gene Ontology</term><term>Humains</term><term>Navigateur</term><term>Vésicules extracellulaires (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Extracellular Vesicles</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN</term><term>Vésicules extracellulaires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Databases, Genetic</term><term>Gene Ontology</term><term>Humans</term><term>Molecular Sequence Annotation</term><term>Web Browser</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Annotation de séquence moléculaire</term><term>Bases de données génétiques</term><term>Gene Ontology</term><term>Humains</term><term>Navigateur</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>To address the lack of standard terminology to describe extracellular RNA (exRNA) data/metadata, we have launched an inter-community effort to extend the Gene Ontology (GO) with subcellular structure concepts relevant to the exRNA domain. By extending GO in this manner, the exRNA data/metadata will be more easily annotated and queried because it will be based on a shared set of terms and relationships relevant to extracellular research.</p></sec><sec><title>Methods</title><p>By following a consensus-building process, we have worked with several academic societies/consortia, including ERCC, ISEV, and ASEMV, to identify and approve a set of exRNA and extracellular vesicle-related terms and relationships that have been incorporated into GO. In addition, we have initiated an ongoing process of extractions of gene product annotations associated with these terms from Vesiclepedia and ExoCarta, conversion of the extracted annotations to Gene Association File (GAF) format for batch submission to GO, and curation of the submitted annotations by the GO Consortium. As a use case, we have incorporated some of the GO terms into annotations of samples from the exRNA Atlas and implemented a faceted search interface based on such annotations.</p></sec><sec><title>Results</title><p>We have added 7 new terms and modified 9 existing terms (along with their synonyms and relationships) to GO. Additionally, 18,695 unique coding gene products (mRNAs and proteins) and 963 unique non-coding gene products (ncRNAs) which are associated with the terms: “extracellular vesicle”, “extracellular exosome”, “apoptotic body”, and “microvesicle” were extracted from ExoCarta and Vesiclepedia. These annotations are currently being processed for submission to GO.</p></sec><sec><title>Conclusions</title><p>As an inter-community effort, we have made a substantial update to GO in the exRNA context. We have also demonstrated the utility of some of the new GO terms for sample annotation and metadata search.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Huang, X" uniqKey="Huang X">X Huang</name></author><author><name sortKey="Yuan, T" uniqKey="Yuan T">T Yuan</name></author><author><name sortKey="Tschannen, M" uniqKey="Tschannen M">M Tschannen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Zheng, Q" uniqKey="Zheng Q">Q Zheng</name></author><author><name sortKey="Bao, C" uniqKey="Bao C">C Bao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takahashi, K" uniqKey="Takahashi K">K Takahashi</name></author><author><name sortKey="Yan, Ik" uniqKey="Yan I">IK Yan</name></author><author><name sortKey="Kogure, T" uniqKey="Kogure T">T Kogure</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skog, J" uniqKey="Skog J">J Skog</name></author><author><name sortKey="Wurdinger, T" uniqKey="Wurdinger T">T Wurdinger</name></author><author><name sortKey="Van Rijn, S" uniqKey="Van Rijn S">S van Rijn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gezer, U" uniqKey="Gezer U">U Gezer</name></author><author><name sortKey="Ozgur, E" uniqKey="Ozgur E">E Ozgur</name></author><author><name sortKey="Cetinkaya, M" uniqKey="Cetinkaya M">M Cetinkaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patton, Jg" uniqKey="Patton J">JG Patton</name></author><author><name sortKey="Franklin, Jl" uniqKey="Franklin J">JL Franklin</name></author><author><name sortKey="Weaver, Am" uniqKey="Weaver A">AM Weaver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valadi, H" uniqKey="Valadi H">H Valadi</name></author><author><name sortKey="Ekstrom, K" uniqKey="Ekstrom K">K Ekstrom</name></author><author><name sortKey="Bossios, A" uniqKey="Bossios A">A Bossios</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nolte Hoen, En" uniqKey="Nolte Hoen E">EN Nolte-‘t Hoen</name></author><author><name sortKey="Buermans, Hp" uniqKey="Buermans H">HP Buermans</name></author><author><name sortKey="Waasdorp, M" uniqKey="Waasdorp M">M Waasdorp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arroyo, Jd" uniqKey="Arroyo J">JD Arroyo</name></author><author><name sortKey="Chevillet, Jr" uniqKey="Chevillet J">JR Chevillet</name></author><author><name sortKey="Kroh, Em" uniqKey="Kroh E">EM Kroh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vickers, Kc" uniqKey="Vickers K">KC Vickers</name></author><author><name sortKey="Palmisano, Bt" uniqKey="Palmisano B">BT Palmisano</name></author><author><name sortKey="Shoucri, Bm" uniqKey="Shoucri B">BM Shoucri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Jm" uniqKey="Taylor J">JM Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunn, Mm" uniqKey="Dunn M">MM Dunn</name></author><author><name sortKey="Olsen, Jc" uniqKey="Olsen J">JC Olsen</name></author><author><name sortKey="Swanstrom, R" uniqKey="Swanstrom R">R Swanstrom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vogt, Vm" uniqKey="Vogt V">VM Vogt</name></author><author><name sortKey="Eisenman, R" uniqKey="Eisenman R">R Eisenman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duesberg, Ph" uniqKey="Duesberg P">PH Duesberg</name></author><author><name sortKey="Martin, Gs" uniqKey="Martin G">GS Martin</name></author><author><name sortKey="Vogt, Pk" uniqKey="Vogt P">PK Vogt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rifkin, D" uniqKey="Rifkin D">D Rifkin</name></author><author><name sortKey="Compans, Rw" uniqKey="Compans R">RW Compans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petry, H" uniqKey="Petry H">H Petry</name></author><author><name sortKey="Goldmann, C" uniqKey="Goldmann C">C Goldmann</name></author><author><name sortKey="Ast, O" uniqKey="Ast O">O Ast</name></author><author><name sortKey="Luke, W" uniqKey="Luke W">W Luke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wagner, J" uniqKey="Wagner J">J Wagner</name></author><author><name sortKey="Riwanto, M" uniqKey="Riwanto M">M Riwanto</name></author><author><name sortKey="Besler, C" uniqKey="Besler C">C Besler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Chen, C" uniqKey="Chen C">C Chen</name></author><author><name sortKey="Zhou, F" uniqKey="Zhou F">F Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turchinovich, A" uniqKey="Turchinovich A">A Turchinovich</name></author><author><name sortKey="Weiz, L" uniqKey="Weiz L">L Weiz</name></author><author><name sortKey="Langheinz, A" uniqKey="Langheinz A">A Langheinz</name></author><author><name sortKey="Burwinkel, B" uniqKey="Burwinkel B">B Burwinkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Claude, A" uniqKey="Claude A">A Claude</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Hc" uniqKey="Anderson H">HC Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolf, P" uniqKey="Wolf P">P Wolf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trams, Eg" uniqKey="Trams E">EG Trams</name></author><author><name sortKey="Lauter, Cj" uniqKey="Lauter C">CJ Lauter</name></author><author><name sortKey="Salem, N" uniqKey="Salem N">N Salem</name></author><author><name sortKey="Heine, U" uniqKey="Heine U">U Heine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnstone, Rm" uniqKey="Johnstone R">RM Johnstone</name></author><author><name sortKey="Adam, M" uniqKey="Adam M">M Adam</name></author><author><name sortKey="Hammond, Jr" uniqKey="Hammond J">JR Hammond</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hess, C" uniqKey="Hess C">C Hess</name></author><author><name sortKey="Sadallah, S" uniqKey="Sadallah S">S Sadallah</name></author><author><name sortKey="Hefti, A" uniqKey="Hefti A">A Hefti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cocucci, E" uniqKey="Cocucci E">E Cocucci</name></author><author><name sortKey="Meldolesi, J" uniqKey="Meldolesi J">J Meldolesi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Brody, I" uniqKey="Brody I">I Brody</name></author><author><name sortKey="Ronquist, G" uniqKey="Ronquist G">G Ronquist</name></author><author><name sortKey="Gottfries, A" uniqKey="Gottfries A">A Gottfries</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sullivan, R" uniqKey="Sullivan R">R Sullivan</name></author><author><name sortKey="Saez, F" uniqKey="Saez F">F Saez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perrin, P" uniqKey="Perrin P">P Perrin</name></author><author><name sortKey="Sureau, P" uniqKey="Sureau P">P Sureau</name></author><author><name sortKey="Thibodeau, L" uniqKey="Thibodeau L">L Thibodeau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Derdak, Sv" uniqKey="Derdak S">SV Derdak</name></author><author><name sortKey="Kueng, Hj" uniqKey="Kueng H">HJ Kueng</name></author><author><name sortKey="Leb, Vm" uniqKey="Leb V">VM Leb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Di Vizio, D" uniqKey="Di Vizio D">D Di Vizio</name></author><author><name sortKey="Kim, J" uniqKey="Kim J">J Kim</name></author><author><name sortKey="Hager, Mh" uniqKey="Hager M">MH Hager</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karlsson, M" uniqKey="Karlsson M">M Karlsson</name></author><author><name sortKey="Lundin, S" uniqKey="Lundin S">S Lundin</name></author><author><name sortKey="Dahlgren, U" uniqKey="Dahlgren U">U Dahlgren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subramanian, Sl" uniqKey="Subramanian S">SL Subramanian</name></author><author><name sortKey="Kitchen, Rr" uniqKey="Kitchen R">RR Kitchen</name></author><author><name sortKey="Alexander, R" uniqKey="Alexander R">R Alexander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noy, Nf" uniqKey="Noy N">NF Noy</name></author><author><name sortKey="Shah, Nh" uniqKey="Shah N">NH Shah</name></author><author><name sortKey="Whetzel, Pl" uniqKey="Whetzel P">PL Whetzel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ashburner, M" uniqKey="Ashburner M">M Ashburner</name></author><author><name sortKey="Ball, C" uniqKey="Ball C">C Ball</name></author><author><name sortKey="Blake, Ja" uniqKey="Blake J">JA Blake</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mungall, Cj" uniqKey="Mungall C">CJ Mungall</name></author><author><name sortKey="Torniai, C" uniqKey="Torniai C">C Torniai</name></author><author><name sortKey="Gkoutos, Gv" uniqKey="Gkoutos G">GV Gkoutos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hastings, J" uniqKey="Hastings J">J Hastings</name></author><author><name sortKey="De Matos, P" uniqKey="De Matos P">P de Matos</name></author><author><name sortKey="Dekker, A" uniqKey="Dekker A">A Dekker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooper, L" uniqKey="Cooper L">L Cooper</name></author><author><name sortKey="Walls, Rl" uniqKey="Walls R">RL Walls</name></author><author><name sortKey="Elser, J" uniqKey="Elser J">J Elser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gkoutos, Gv" uniqKey="Gkoutos G">GV Gkoutos</name></author><author><name sortKey="Green, Ec" uniqKey="Green E">EC Green</name></author><author><name sortKey="Mallon, Am" uniqKey="Mallon A">AM Mallon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eilbeck, K" uniqKey="Eilbeck K">K Eilbeck</name></author><author><name sortKey="Lewis, Se" uniqKey="Lewis S">SE Lewis</name></author><author><name sortKey="Mungall, Cj" uniqKey="Mungall C">CJ Mungall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alam Faruque, Y" uniqKey="Alam Faruque Y">Y Alam-Faruque</name></author><author><name sortKey="Hill, Dp" uniqKey="Hill D">DP Hill</name></author><author><name sortKey="Dimmer, Ec" uniqKey="Dimmer E">EC Dimmer</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kalra, H" uniqKey="Kalra H">H Kalra</name></author><author><name sortKey="Simpson, Rj" uniqKey="Simpson R">RJ Simpson</name></author><author><name sortKey="Ji, H" uniqKey="Ji H">H Ji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schriml, Lm" uniqKey="Schriml L">LM Schriml</name></author><author><name sortKey="Arze, C" uniqKey="Arze C">C Arze</name></author><author><name sortKey="Nadendla, S" uniqKey="Nadendla S">S Nadendla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dahdul, Wm" uniqKey="Dahdul W">WM Dahdul</name></author><author><name sortKey="Balhoff, Jp" uniqKey="Balhoff J">JP Balhoff</name></author><author><name sortKey="Blackburn, Dc" uniqKey="Blackburn D">DC Blackburn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, Dg" uniqKey="Thomas D">DG Thomas</name></author><author><name sortKey="Pappu, Rv" uniqKey="Pappu R">RV Pappu</name></author><author><name sortKey="Baker, Na" uniqKey="Baker N">NA Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malone, J" uniqKey="Malone J">J Malone</name></author><author><name sortKey="Holloway, E" uniqKey="Holloway E">E Holloway</name></author><author><name sortKey="Adamusiak, T" uniqKey="Adamusiak T">T Adamusiak</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Pays-Bas</li><li>Suède</li><li>États-Unis</li></country><region><li>Californie</li><li>Connecticut</li><li>Floride</li><li>Maryland</li><li>Rhode Island</li><li>Tennessee</li><li>Texas</li><li>Utrecht (province)</li><li>Washington (État)</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Utrecht</li></settlement><orgName><li>Université d'Utrecht</li></orgName></list><tree><noCountry><name sortKey="Anand, Sushma" sort="Anand, Sushma" uniqKey="Anand S" first="Sushma" last="Anand">Sushma Anand</name><name sortKey="Gangoda, Lahiru" sort="Gangoda, Lahiru" uniqKey="Gangoda L" first="Lahiru" last="Gangoda">Lahiru Gangoda</name><name sortKey="Hill, Andrew F" sort="Hill, Andrew F" uniqKey="Hill A" first="Andrew F." last="Hill">Andrew F. Hill</name><name sortKey="Keerthikumar, Shivakumar" sort="Keerthikumar, Shivakumar" uniqKey="Keerthikumar S" first="Shivakumar" last="Keerthikumar">Shivakumar Keerthikumar</name><name sortKey="Mathivanan, Suresh" sort="Mathivanan, Suresh" uniqKey="Mathivanan S" first="Suresh" last="Mathivanan">Suresh Mathivanan</name><name sortKey="Roncaglia, Paola" sort="Roncaglia, Paola" uniqKey="Roncaglia P" first="Paola" last="Roncaglia">Paola Roncaglia</name><name sortKey="Samuel, Monisha" sort="Samuel, Monisha" uniqKey="Samuel M" first="Monisha" last="Samuel">Monisha Samuel</name><name sortKey="Shypitsyna, Aleksandra" sort="Shypitsyna, Aleksandra" uniqKey="Shypitsyna A" first="Aleksandra" last="Shypitsyna">Aleksandra Shypitsyna</name></noCountry><country name="États-Unis"><region name="Connecticut"><name sortKey="Cheung, Kei Hoi" sort="Cheung, Kei Hoi" uniqKey="Cheung K" first="Kei-Hoi" last="Cheung">Kei-Hoi Cheung</name></region><name sortKey="Alexander, Roger" sort="Alexander, Roger" uniqKey="Alexander R" first="Roger" last="Alexander">Roger Alexander</name><name sortKey="Cheung, Kei Hoi" sort="Cheung, Kei Hoi" uniqKey="Cheung K" first="Kei-Hoi" last="Cheung">Kei-Hoi Cheung</name><name sortKey="Galas, David" sort="Galas, David" uniqKey="Galas D" first="David" last="Galas">David Galas</name><name sortKey="Gerstein, Mark B" sort="Gerstein, Mark B" uniqKey="Gerstein M" first="Mark B." last="Gerstein">Mark B. Gerstein</name><name sortKey="Gerstein, Mark B" sort="Gerstein, Mark B" uniqKey="Gerstein M" first="Mark B." last="Gerstein">Mark B. Gerstein</name><name sortKey="Gerstein, Mark B" sort="Gerstein, Mark B" uniqKey="Gerstein M" first="Mark B." last="Gerstein">Mark B. Gerstein</name><name sortKey="Gould, Stephen" sort="Gould, Stephen" uniqKey="Gould S" first="Stephen" last="Gould">Stephen Gould</name><name sortKey="Kitchen, Robert R" sort="Kitchen, Robert R" uniqKey="Kitchen R" first="Robert R." last="Kitchen">Robert R. Kitchen</name><name sortKey="Laurent, Louise C" sort="Laurent, Louise C" uniqKey="Laurent L" first="Louise C." last="Laurent">Louise C. Laurent</name><name sortKey="Milosavljevic, Aleksandar" sort="Milosavljevic, Aleksandar" uniqKey="Milosavljevic A" first="Aleksandar" last="Milosavljevic">Aleksandar Milosavljevic</name><name sortKey="Patel, Tushar" sort="Patel, Tushar" uniqKey="Patel T" first="Tushar" last="Patel">Tushar Patel</name><name sortKey="Procaccini, Dena C" sort="Procaccini, Dena C" uniqKey="Procaccini D" first="Dena C." last="Procaccini">Dena C. Procaccini</name><name sortKey="Quesenberry, Peter" sort="Quesenberry, Peter" uniqKey="Quesenberry P" first="Peter" last="Quesenberry">Peter Quesenberry</name><name sortKey="Raffai, Robert L" sort="Raffai, Robert L" uniqKey="Raffai R" first="Robert L." last="Raffai">Robert L. Raffai</name><name sortKey="Roth, Matthew E" sort="Roth, Matthew E" uniqKey="Roth M" first="Matthew E." last="Roth">Matthew E. Roth</name><name sortKey="Rozowsky, Joel" sort="Rozowsky, Joel" uniqKey="Rozowsky J" first="Joel" last="Rozowsky">Joel Rozowsky</name><name sortKey="Rozowsky, Joel" sort="Rozowsky, Joel" uniqKey="Rozowsky J" first="Joel" last="Rozowsky">Joel Rozowsky</name><name sortKey="Su, Andrew I" sort="Su, Andrew I" uniqKey="Su A" first="Andrew I." last="Su">Andrew I. Su</name><name sortKey="Subramanian, Sai Lakshmi" sort="Subramanian, Sai Lakshmi" uniqKey="Subramanian S" first="Sai Lakshmi" last="Subramanian">Sai Lakshmi Subramanian</name><name sortKey="Vickers, Kasey" sort="Vickers, Kasey" uniqKey="Vickers K" first="Kasey" last="Vickers">Kasey Vickers</name></country><country name="Suède"><noRegion><name sortKey="Lotvall, Jan" sort="Lotvall, Jan" uniqKey="Lotvall J" first="Jan" last="Lötvall">Jan Lötvall</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Thery, Clotilde" sort="Thery, Clotilde" uniqKey="Thery C" first="Clotilde" last="Théry">Clotilde Théry</name></region></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Wauben, Marca H M" sort="Wauben, Marca H M" uniqKey="Wauben M" first="Marca H. M." last="Wauben">Marca H. M. Wauben</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F19 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001F19 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4830068
|texte= Extending gene ontology in the context of extracellular RNA and vesicle communication
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27076901" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |